B. alba leaves and a methanolic extract of the leaves inhibited the growth of S. litura larvae. When the scavenging receptor for oxidized LDL on macrophages is upregulated, it leads to foam cells formation which are the major component of fatty streaks. This ingredient is … Basella alba has been used for many of its useful product from ancient times. The hypercholesterolemia-induced rabbits showed significant increase () in ALT, AST, and CK levels as presented in Table 3. The crude methanolic extract of B. alba was concentrated using rotary evaporator (Heidolph) under reduced pressure at 40°C and freeze-dried at −40°C for further analysis. The rabbits administered simvastatin or B. alba extract had reduction in body weight and serum levels of TC, LDL, and TG and significant increase noted in HDL levels. Commonly grown in South Asian countries is now gaining popularity in some of tropical and temperature climates of America, Europe, … The serum levels of ALT, AST, and creatine kinase (CK) were evaluated by enzymatic kit (Randox Laboratories, Crumlin, UK) using Hitachi chemistry analyzer (Tokyo, Japan). B. alba (200 mg/kg) increases the HDL level more effectively than simvastatin. It is commonly grown as backyard plant or in the home garden. After filtration, the residue obtained was again resuspended in equal volume of 95% ethanol for 48h and filtered again. Stems are purplish or green. chapter four 4.0 results and discussion. 2015;6(4):246–254. Title The New RHS Dictionary of Gardening. 6. Therefore, in the present investigation, a widely consumable vegetable Basella alba was subjected to evaluate its antiproliferative effect along with molecular signaling of apoptosis in Ehrlich ascites carcinoma (EAC) cell line. There are no other known side effects. 4. Simvastatin and B. alba-treated rabbits revealed a significant reduction in aortic plaque and intimal thickening. Thus, B. alba was examined in order to investigate its phytochemical components. The present study was aimed to evaluate the efficacy of Basella alba and Tribulus terrestris for induction of B. alba leaves and T. terrestris seeds were extracted with water, ethanol, methanol, dichloromethane, hexane and successive methanol and mixed sex juveniles of Nile tilapia were subjected to dietary treatment with the extracts at the concentration of 0.5, 1.0 and 1.5 gm/kg feed. Normal control group (G1) showed healthy aorta with uniform thickness and intact endothelial lining. -. B. Waqar, T. Koike, Y. Yu et al., “High-fat diet without excess calories induces metabolic disorders and enhances atherosclerosis in rabbits,”, Y. Kureishi, Z. Luo, I. Shiojima et al., “The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals,”, Y. Zhang, L. Li, J. Basella alba, la baselle ou épinard de Malabar, est une espèce de plantes dicotylédones de la famille des Basellaceae, probablement originaire d'Asie du Sud. This study was designed to investigate the hypocholesterolemic and antiatherosclerotic effects of Basella alba ( B. alba ) using … The Basella alba leaves were subjected to cold … Twenty New Zealand white rabbits were divided into 5 groups and fed with varying diets: normal diet, 2% high cholesterol diet (HCD), 2% HCD + 10 mg/kg simvastatin, 2% HCD + 100 mg/kg B. alba extract, and 2% HCD + 200 mg/kg B. alba extract, respectively. This study was designed to investigate the hypocholesterolemic and antiatherosclerotic effects of Basella alba (B. alba) using hypercholesterolemia-induced rabbits. Basella alba (B. alba) extract showed the highest enzyme inhibition, about 74% [5]. With low calorie and high nutrients, it is a healthy food that you prefer. Serum total cholesterol (TC), LDL, HDL, and triglycerides (TG) levels were determined using Roche kit (Penzberg, Germany) and measured spectrophotometrically using Hitachi chemistry analyzer (Tokyo, Japan). Odor : Characteristic. The rabbits were randomly divided into 5 groups (): Group 1: control rabbits fed with standard diet for 12 weeks; Group 2: rabbits fed with 2% high cholesterol diet (HCD) for 12 weeks; Group 3: rabbits fed with 2% HCD for 8 weeks and treatment with simvastatin (10 mg/kg) for 4 weeks; Group 4: rabbits fed with 2% HCD for 8 weeks and treatment with B. alba extract (100 mg/kg) for 4 weeks; and Group 5: rabbits fed with 2% HCD for 8 weeks and treatment with B. alba extract (200 mg/kg) for 4 weeks. There are two types, Basella alba and Basella rubra. Antioxidant enzymes (SOD and GPx) play essential roles in maintaining the physiological concentrations of oxygen and hydrogen peroxide by improving the dismutation of oxygen radicals [20]. B. alba successfully inhibited the atherosclerotic plaque formation in hypercholesterolemia-induced model. Basella alba is a succulent, branched, twining herbaceous, perennial plant which is cultivated as a vegetable.This plant is also known as Malabar spinach, Indian spinach, Ceylon spinach, East-Indian spinach, Vine spinach, Climbing spinach, Chinese spinach, Cyclone spinach and Alugbati.. Malabar spinach is an edible flowering plant in family Basellaceae native to tropical Southern Asia which was … Levels of antioxidant enzymes in serum of rabbits from various groups. No need to register, buy now! Grows well under full sunlight in hot, humid climates. Basella Alba will help get the engine roaring again as part of a complete post cycle therapy. Journal of Pharmacognosy and Phytochemistry. Significant increase in HDL as shown in B. alba-treated rabbits is a desirable criterion for an ideal hypercholesterolemic agent since it reduces the atherosclerotic risk. Basella alba is a perennial plant of the Basellaceae and is known by various common names including Malabar spinach. The antioxidant activity assay of leaf and seed extracts of B. alba along…, Hemagglutination activity of leaf and seed of B. alba . Leaf extracts showed…, Cytotoxic activity of leaf and seed extract of B. alba . Along with unique quality if nutrient, it … This tender perennial native to tropical Asia, likely India and Sri Lanka or Indonesia (hardy only to zone 10), is easily grown as an annual during the heat of summer. After filtration, the leaf extract was isolated using a separatory funnel. Sign up here as a reviewer to help fast-track new submissions. Readable … Morphological alteration under fluorescence microscope showed nuclear condensation and fragmentation which is the sign of apoptosis. Besides, it is believed to protect the body from cardiovascular diseases and cancers of the colon. See this image and copyright information in PMC. A. Does Basella Alba Cause Side Effects? Other common names include Vine Spinach, Red Vine Spinach, Creeping Spinach, and Ceylon Spinach. Publisher MacMillan Press Year 1992 ISBN 0-333-47494-5 Description Excellent and very comprehensive, though it contains a number of silly mistakes. In this study, 25 medicinal plant methanol extracts were screened for anti-HMG-CoA reductase activity. The Basella alba leaves were subjected to cold … Present study was conducted to inquire the effects of methanol extract from Basella alba leaf (MEBA) against diabetic nephropathy in rats. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. 2020 Aug;44(8):e13342. Ce sont des plantes herbacées grimpantes, vivaces à courte durée de vie, à petites fleurs groupées en épis axillaires. Characterization and evaluation of antibacterial and antiproliferative activities of crude protein extracts isolated from the seed of Ricinus communis in Bangladesh. Basella alba L.. SYNONYM(S) : Basella cordifolia Lam. Part used : Whole herb. CHINESE : Chan cai (Cantonese Saan choi, Shan ts'oi), Luo kui (Lor kwai), Qing chan cai (Cantonese Tsing shan tsoi), Mu er cai, Lü luo kui. BURMESE : Ginbeik, King-peim.ni. Baskaran Gunasekaran is supported by Ministry of Education (MOE) of Malaysia. English Name – Indian spinach, Malabar spinach, Indian spinach, Ceylon spinach, Vine spinach Sanskrit Name – Pothaki Hindi name – Poya, poi, Lalbachlu Bengali Name – … Basella cananifolia Buch.-Ham. Nowadays, alternative treatment using medicinal plants gained much attention since the usage of statins leads to adverse health effects, especially liver and muscle toxicity. Cancer is a class of diseases characterized by uncontrolled cell growth. Meanwhile, simvastatin-treated groups showed significant reduction () in SOD and GPx, 4 and 19%, respectively. Rat Leydig cells were … English Name – Indian spinach, Malabar spinach, Indian spinach, Ceylon spinach, Vine spinach Sanskrit Name – Pothaki Hindi name – Poya, poi, Lalbachlu Bengali Name – Poome, Puishaka Marathi Name – Maayala, Velbendi, Mayalu Gujarati Name – Pothi Kannada Name – Basale soppu Tulu Name – Basale Malayalam Name – Vasalaccira, Cheera, Vallicheera Telugu Name – Bachhali Tamil Name – Basalakira, Vasalakkirai, Ko… Akin to spinach, regular consumption of basella (Malabar spinach) in the diet helps prevent osteoporosis (weakness of bones), iron-deficiency anemia. International Journal of Phytopharmacology. Further investigations are needed on the mechanisms of B. alba in inhibiting the atherosclerotic plaque formation. There are few insects that cause damage to B. alba. doi: 10.1016/S1995-7645(14)60272-8. Its leaves are thick, semi-succulent, heart-shaped having a mild flavour and mucilaginous texture. Basella … The diets were vacuum-packed and stored in −20°C freezer. B. alba leaf was purchased from a local market in Seri Kembangan, Selangor, Malaysia. A. Adaramoye, O. Akintayo, J. Achem, and M. A. Fafunso, “Lipid-lowering effects of methanolic extract of, F. Martinello, S. M. Soares, J. J. Franco et al., “Hypolipemic and antioxidant activities from, S. Bolkent, R. Yanardag, S. Bolkent, and M. M. Döger, “Beneficial effects of combined treatment with niacin and chromium on the liver of hyperlipemic rats,”, R. S. Scott, C. J. Lintott, and M. J. Wilson, “Simvastatin and side effects,”, M. I. Kazeem, M. A. Akanji, M. T. Yakubu, and A. O. T. Ashafa, “Protective effect of free and bound polyphenol extracts from ginger (, M. Trocha, A. Merwid-Lad, E. Chlebda, M. Pieśniewska, T. Sozański, and A. Szelag, “Effect of simvastatin treatment on rat livers subjected to ischemia/reperfusion,”, K. Prasad and J. Kalra, “Oxygen free radicals and hypercholesterolemic atherosclerosis: effect of vitamin E,”, M. A. Mikail, I. Huge collection, amazing choice, 100+ million high quality, affordable RF and RM images. Excess LDL is mostly deposited in arterial wall and becomes a main component of atherosclerotic plaque formation, while HCD feeding has been reported to reduce fatty acid oxidation, resulting in the increase of serum TG which is considered as another risk factor for CVDs [13]. It is native to the Indian subcontinent, Southeast Asia and New Guinea. The data obtained in this study suggested that B. alba extract is capable of enhancing the activity of SOD and GPx in hypercholesterolemia-induced rabbits; the effect could be due to the presence of phenolic compounds. Its flowers possess the attributes of an Antidote. Toxicol Res. The results from the present study showed that B. alba extract (200 mg/kg) effectively reduces the levels of TC, LDL, and TG and raised the level of HDL and antioxidants enzymes. The Glutathione Peroxidase (GPx) activity was measured by diluting 0.05 mL serum with 2 mL of RANSEL kit diluting agent (Randox Laboratories, Crumlin, UK) and the mixture was read at 340 nm using Vitalab Selectra Analyzer (Merck, Darmstadt, Germany). B. alba is known as Indian spinach and Remayung locally and belongs to the family of Basellaceae. As shown in Table 4, the hypercholesterolemic control showed significant reduction () in the levels of SOD and GPx throughout the study. Title The New RHS Dictionary of Gardening. These enzymes were reported to leak into the blood circulation when their cell membranes were injured [17]. The mechanism by which B. alba inhibits the atherosclerotic plaque is not known but may be due to its antioxidant, hypocholesterolemic, and antiatherosclerotic effects such as decreasing oxidative stress, lowering the LDL level, reducing inflammation, and inhibiting macrophage accumulation. An ethnomedicine survey in southern India revealed that Basella alba is one of the plants used for the treatment of apthae. Basella cananifolia Buch.-Ham. B. alba leaf extract did not cause liver and muscle damage indicating that it is safe for consumption. This variety can't be distinguished in the … About equal level of expression was found in GAPDH mRNA and upregulation of p53 and downregulation of antiapoptotic Bcl-2 were found in the treated cells compared to control. belongs to the Basellaceae family and has two chief cultivars, Basella alba that has green-stems and deep-green leaves, and B. rubra with purplish stems and dark green leaves with pink veins [1]. Malabar spinach may be used to thicken soups or as a leafy … Growth is slow in low temperatures resulting in low yields. & Moldenke. The combination has been found to increase testosterone in rats, and Basella appears to … Significant differences of values are compared to values of control and treated samples and marked as (. On the other hand, significant reductions () were noted in the thickness of intima and media as well as intima/media ratio of simvastatin and B. alba (100 and 200 mg/kg) treated groups compared to the hypercholesterolemic control group. Effects of B. alba on fasting blood glucose in stressed rats The FBG of group 4 (85.2 ± 1.49 mg/dL) and group 5 (72.8 ± 1.36 mg/dL) rats given 60 mg/kg of B. alba extract at the end of the second week were significantly higher than normal control (54.4 ± 1.86 mg/dL) but significantly lower than stress control (groups 2) (106.2 ± 4.55 mg/dL) and group 3 (114.86 ± 6.12 mg/dL). Butylated hydroxyanisole (0.02% of diet) was dissolved in chloroform to reduce oxidation of cholesterol. G1: normal control, G2: hypercholesterolemic control, G3: simvastatin-treated (10 mg/kg), G4: T. Yokozawa, E. J. Cho, S. Sasaki, A. Satoh, T. Okamoto, and Y. Sei, “The protective role of Chinese prescription Kangen-karyu extract on diet-induced hypercholesterolemia in rats,”, S. K. Yeap, B. K. Beh, W. Y. Ho et al., “In vivo antioxidant and hypolipidemic effects of fermented mung bean on hypercholesterolemic mice,”, S. Salvamani, B. Gunasekaran, N. A. Shaharuddin, S. A. Ahmad, and M. Y. Shukor, “Antiartherosclerotic effects of plant flavonoids,”, M. F. Ismail, M. Z. Gad, and M. A. Hamdy, “Study of the hypolipidemic properties of pectin, garlic and ginseng in hypercholesterolemic rabbits,”, G. Baskaran, S. Salvamani, S. A. Ahmad, N. A. Shaharuddin, P. D. Pattiram, and M. Y. Shukor, “HMG-CoA reductase inhibitory activity and phytocomponent investigation of, R. Adhikari, K. H. Naveen, and S. Shruthi, “A review on medicinal importance of, H. Yasmin, M. A. Kaisar, M. M. R. Sarker, M. S. Rahman, and M. A. Rashid, “Preliminary anti-bacterial activity of some indigenous plants of Bangladesh,”, P. Balachandran and R. Govindarajan, “Cancer—an ayurvedic perspective,”, A. Saag, পুঁই শাক Pui shaak afr J Biotechnol, 9, 2010, 6952-6955 CK ( 24.2 and %. Successfully inhibited the atherosclerotic changes in aortic plaque and intimal thickening ANOVA ) followed by Dunnett ’ post! And seed extract pregnant women to reduce oxidation of cholesterol in vitamin a, vitamin c, iron calcium! Groups showed significant reduction ( ) in the Institute of Bioscience, Universiti Putra Malaysia, Grant.! An essential role in protecting the membranes against oxidative damage the muscle injury, GRIN.... The exact makeup of these pills or supplements, they may have a mild flavour and texture... [ 23, 24 ] and GPx, 4 and 19 %,.... 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